Synthesis and In vitro Testing of Novel Quinoline Derivatives and for Cancer Cells

Quinoline and its derivatives represent an important class of nitrogen containing heterocycles because they are useful intermediates in organic synthesis biological activities such as antiasthmatic, anti-inflammatory, anti- cancer, antimalarial activity. A quinoline eight compounds was successfully synthesized characterized by FT-IR, 1H NMR, 13C NMR mass spectral analysis. Therefore, the new with strong pharmacological activity is medicine. There significant research focused on development quinoline-based structures methods synthesis. In this study, were several spectroscopic techniques, these evaluated using lung cancer cell lines molecular modeling enzymatic system. The tested for their potential lines. Eight (K1- K8) cytotoxic activities. anticancer test showed that K2, K3 K4 show good Among them, K2 shown to be dose-dependent, having highest toxicity at 250 µM K8 125, 250, 500 µM, while K1, K5, K6, K7 not cytotoxic.